When looking through the store during a game;
The first item that you buy should usually be a regen item, or a gold generating item.
the second item that you buy should usually be some boots, or in certain cases like Warwick, something champion-specific like Life Steal.
After that you should build up something for your certain champion.
For instance:
If you are a AP-using champion like Veigar or Morgana, then buy a LOT of Ability Power items.
If you are a tank, then you should buy a LOT of health-bonus, health-regen, or armor items.
If you are a melee, then you should most likely buy a lot of damage and life steal, but this may change with some champions.
In general, you would need a detailed guide for each champion which will happen in time- for now, just learn things for yourself and you should do well enough, also other guides on this site can help you learn faster.
The first item that you buy should usually be a regen item, or a gold generating item.
the second item that you buy should usually be some boots, or in certain cases like Warwick, something champion-specific like Life Steal.
After that you should build up something for your certain champion.
For instance:
If you are a AP-using champion like Veigar or Morgana, then buy a LOT of Ability Power items.
If you are a tank, then you should buy a LOT of health-bonus, health-regen, or armor items.
If you are a melee, then you should most likely buy a lot of damage and life steal, but this may change with some champions.
In general, you would need a detailed guide for each champion which will happen in time- for now, just learn things for yourself and you should do well enough, also other guides on this site can help you learn faster.